Product Size
1 x 96 tests
Custom Size
Product Information
Sample Type
Cell Culture Supernatant, Serum, Cell Culture Extracts, Tissue Extracts, Hep Plasma, Cit Plasma
Assay Type
Sandwich (quantitative)
Range
93.75 pg/mL-6000 pg/mL
Detection Method
Colorimetric
Target Information
Function
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May play a role in neoplasia. May counteract a default induction of apoptosis in G2/M phase. Inhibitor of caspase-3 and caspase-7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.
Sequence Similarities
Belongs to the IAP family. Contains 1 BIR repeat.
Alternative Names
API4; Apoptosis inhibitor 4; Apoptosis inhibitor survivin; Apoptosis inhibitor4; Baculoviral IAP repeat containing 5; Baculoviral IAP repeat containing protein 5; Baculoviral IAP repeat-containing protein 5; BIRC 5; BIRC5; BIRC5_HUMAN; EPR 1; IAP4; Survivin variant 3 alpha; SVV; TIAP
Tissue Specificity
Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage Instructions
Store at 4 °C. Please refer to protocols.
