Product Size
1 x 96 tests
Custom Size
Product Information
Sample Type
Cell Culture Extracts, Tissue Extracts
Assay Type
Sandwich (quantitative)
Range
62.5 pg/mL-4000 pg/mL
Detection Method
Colorimetric
Target Information
Function
May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
Sequence Similarities
Belongs to the CDI family.
Alternative Names
CAP20; CDK-interacting protein 1; CDKI; CDKN1; Cdkn1a; CDN1A_HUMAN; CIP1; Cyclin Dependent Kinase Inhibitor 1A; Cyclin-dependent kinase inhibitor 1; Cyclin-dependent kinase inhibitor 1A (P21); Cyclin-dependent kinase inhibitor 1A (p21, Cip1); DNA Synthesis Inhibitor; MDA-6; MDA6; Melanoma differentiation-associated protein; Melanoma differentiation-associated protein 6; p21; P21 protein; p21CIP1; p21Cip1/Waf1; p21WAF; PIC1; SDI1; SLC12A9; WAF1; Wild type p53 activated fragment 1; Wild type p53 activated fragment 1 (WAF1); Wildtype p53-activated fragment 1
Tissue Specificity
Expressed in all adult human tissues, with 5-fold lower levels observed in the brain.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage Instructions
Store at 4 °C. Please refer to protocols.
