Product Size
50 mg
10 mg
Custom Size
Product Overview
Description
Potent and cell permeable mitosis inhibitor. Kinesin Eg5 inhibitor.
Target
Cell permeable mitosis
Biological Description
Potent and cell permeable mitosis inhibitor. Arrests cellular mitosis through kinesin Eg5 inhibition (IC50 = 14 μM). Also slows ADP release, changes Eg5 conformation and alters Eg5 interactions with microtubules.
Solubility Overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM.
Chemical Properties
Chemical Name
1,2,3,4-Tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester
Molecular Weight (Da)
292.35
Molecular Formula
C14H16N2O3S
SMILES
O=C(OCC)C2=C(C)NC(=S)NC2c1cc(O)ccc1
Storage & Handling
Storage Instructions
Store at -20 °C. It is important to note that this product is reported to be light sensitive. Store in the dark. Store under desiccating conditions.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
