Product Size
50 mg
10 mg
Custom Size
Product Overview
Description
Potent, selective myosin light chain kinase inhibitor.
Target
Myosin light chain kinase
Biological Description
Potent and selective myosin light chain kinase inhibitor (MLCK) (Ki = 300 nM). Also inhibits PKA and PKC (Ki values are 21 and 42 μM, respectively). Cell-permeable. Inhibits tumor cell growth.
Solubility Overview
Soluble in DMSO to 100 mM.
Chemical Properties
Chemical Name
Hexahydro-1-[(5-Iodo-1-naphthaleny)sulfonyl]-1H-1,4-diazepine hydrochloride
Molecular Weight (Da)
452.74
Molecular Formula
C15H17IN2O2S.HCl
SMILES
C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CC=C3I.Cl
Storage & Handling
Storage Instructions
Store at -20 °C. Store under desiccating conditions. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
