Product Size
5 mg
50 mg
Custom Size
Product Overview
Description
Potent and selective small-molecule inhibitor of Wee1 kinase.
Alternative Names
AZD 1775; MK1775
Biological Description
Potent and selective small-molecule inhibitor of Wee1 kinase. Inhibits Wee1 (IC50 = 5.2 nM) in cell-free assays. Inhibits phosphorylation of CDC2 at Tyr15 (CDC2Y15), a direct substrate of Wee1 kinase in cell-based assays. Acts synergistically with gemcitabine in tumor cells. In a panel of 223 kinases, only 8 were inhibited >80% by 1μM MK-1775.
Solubility Overview
Soluble in DMSO to 200 mM.
Chemical Properties
Chemical Name
1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-3H-pyrazolo [3,4-d]pyrimidin-3-one
Molecular Weight (Da)
500.60
Molecular Formula
C27H32N8O2
SMILES
CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O
Storage & Handling
Storage Instructions
Shipped at room temperature. Store at -20 °C.
