Mitoxantrone Dihydrochloride, Type II Topoisomerase Inhibitor

Cat. No.
CLIA-0130077
Product Size
50 mg 250 mg Custom Size

Product Overview

Description
Type II topoisomerase inhibitor.
Purity
> 98%
Form
Solid
Target
Type II topoisomerase
Biological Description
Type II topoisomerase inhibitor (IC50 = 50 nM). Able to inhibit DNA and protein synthesis, and induce both DNA strand breakage and cross linkage. Antineoplastic, immunomodulatory and chemotherapeutic action.
Source
Synthetic
CAS Number
70476-82-3
Solubility Overview
Soluble in DMSO to 100 mM and in water to 10 mM.

Chemical Properties

Chemical Name
1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride
Molecular Weight (Da)
517.41
Molecular Formula
C22H28N4O6.2HCl
PubChem Identifier
SMILES
Cl.Cl.OCCNCCNc3ccc(NCCNCCO)c2C(=O)c1c(O)ccc(O)c1C(=O)c23

Storage & Handling

Storage Instructions
Store at room temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

For Research Use Only. Not For Clinical Use.

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