Product Size
25 g
10 g
Custom Size
Product Overview
Description
Phosphatase inhibitor; vitamin K prodrug.
Biological Description
Menadione, a naphthoquinone, can be converted to active vitamin K2 in vivo. Menadione is used as a protein tyrosine phosphatase inhibitor, an inhibitor of mitochondrial DNA polymerase γ (pol γ), and induce DNA strand breaks. Menadione can be used as an oxidative injury (free radical generator) inducing agent, and is ble to prevent erlotinib induced cell-cycle arrest. It has a role as a nutraceutical, a human urinary metabolite, an angiogenesis inhibitor, an SARS coronavirus main proteinase inhibitor and an antineoplastic agent.
Solubility Overview
Soluble in DMSO to 100 mM and ethanol to 50 mM.
Chemical Properties
Chemical Name
2-Methyl-1,4-naphthoquinone
Molecular Weight (Da)
172.18
Molecular Formula
C11H8O2
SMILES
O=C2C=C(C)C(=O)c1ccccc12
Storage & Handling
Storage Instructions
Store at room temperature. Store in the dark. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
