Product Size
1 x 96 tests
Custom Size
Product Information
Reactivity
Mouse, Human (predicted: Rat)
Assay Type
Semi-quantitative
Sample Type
Cell Lysate, Tissue Homogenate
Detection Method
Colorimetric
Target Information
Alternative Names
c jun N terminal kinase 2; c-Jun N-terminal kinase 1; cJun N terminal kinase 1; JNK 1; JNK 2; JNK-46; JNK2ALPHA; JNK2BETA; MAP kinase 8; MAP kinase 9; MAPK 8; mapk8; MAPK9; Mitogen activated protein kinase 8; Mitogen activated protein kinase 9; Mitogen-activated protein kinase 8; MK08_HUMAN; PRKM 8; PRKM 9; Stress-activated protein kinase 1; Stress-activated protein kinase JNK1
Sequence Similarities
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Contains 1 protein kinase domain.
Function
Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage Instructions
Store at 4 °C. Please refer to protocols.
