Product Size
100 tests
Custom Size
Product Information
Reactivity
Mouse, Rat, Human
Sample Type
Adherent Cells, Suspension Cells
Detection Method
Flow cytometry-fluorescent
Target Information
Alternative Names
CSAID-binding protein; Csaids binding protein; CSBP; CSBP1; CSBP2; CSPB1; Cytokine suppressive anti inflammatory drug binding protein; Cytokine suppressive anti-inflammatory drug-binding protein; EXIP; MAP kinase 14; MAP kinase MXI2; MAP kinase p38 alpha; MAPK 14; MAPK14; MAX-interacting protein 2; Mitogen-activated protein kinase 14; Mitogen-activated protein kinase p38 alpha; MK14_HUMAN; Mxi2; p38; p38 MAP kinase; p38 mitogen activated protein kinase; p38alpha; p38alpha Exip; PRKM14; PRKM15; RK; SAPK2A; Stress activated protein kinase 2A
Sequence Similarities
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Contains 1 protein kinase domain.
Tissue Specificity
Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney.
Function
Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage Instructions
Store at -20 °C. Please refer to protocols.
