Product Overview
Reactivity
Human, Mouse (predicted: Rabbit, Horse, Guinea pig, Cow, Pig, Chimpanzee, Rhesus monkey, Gorilla, Chinese hamster, Orangutan, Elephant)
Target Information
Alternative Names
HsMAD 2; HsMAD2; MAD 2; MAD 2A; MAD2 like 1; MAD2 like protein 1; MAD2 mitotic arrest deficient like 1; MAD2-like protein 1; Mad2l1; MD2L1_HUMAN; Mitotic arrest deficient 2-like protein 1; Mitotic arrest deficient yeast homolog like 1; Mitotic spindle assembly checkpoint protein MAD2A
Function
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage
Upon delivery aliquot and store at -20 °C. Avoid freeze / thaw cycles.
Storage Buffer
1.815% Tris, 1.764% Sodium citrate, 0.021% PBS. pH: 7.
Preservative
0.09% Sodium Azide
