MAD1L1/MAD1 Mouse Monoclonal Antibody

Cat. No.: CLAB-00231142

Product Size: 20 µL 100 µL Custom Size

Inquiry

Product Overview

Isotype

IgG2b

Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Conjugation

Unconjugated

Applications

Flow Cyt

Target Information

Target Name

MAD1L1

UniProt No.

Q9Y6D9

Gene ID

8379

Alternative Names

hMAD1; HsMAD1; MAD1; MAD1 mitotic arrest deficient like 1 (yeast); MAD1-like protein 1; MAD1L1; MD1L1_HUMAN; Mitotic arrest deficient 1; Mitotic arrest deficient 1-like protein 1; Mitotic checkpoint MAD1 protein homolog; Mitotic spindle assembly checkpoint protein MAD1; PIG9; Tax binding protein 181; Tax-binding protein 181; TP53I9; Tumor protein p53 inducible protein 9; TXBP181

Function

Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.

Tissue Specificity

Expressed weakly at G0/G1 and highly at late S and G2/M phase.

Shipping & Handling

Shipping

Shipped on dry ice.

Storage

Store at 4 °C short term (1-2 weeks). Upon delivery aliquot. Store at -20 °C or -80 °C. Avoid freeze / thaw cycle.

Storage Buffer

PBS.

Preservative

0.1% Sodium Azide

For Research Use Only. Not For Clinical Use.