Product Size
1 mg
5 mg
Custom Size
Product Overview
Description
Potent inhibitor of DYRKs and CLKs.
Biological Description
Potent inhibitor of DYRKs and CLKs. Interacts also with GSK-3α/β, CK2 and PIM1. Interacts with the complex IKfyve/Vac14/Fig4. Modulates alternative splicing of pre-mRNA in various cellular systems. Neuroprotective against APP-induced cell death. Useful to study and modulate pre-RNA splicing. Potential compound for Alzheimer's disease and diseases involving abnormal pre-mRNA splicing. Potential compound to study Down syndrome (inhibition of DYRK1A). Neuroprotective against glutamate-induced cell death.
Solubility Overview
Soluble in DMSO and in EtOH.
Chemical Properties
Chemical Name
2-anilino-4-(1,3-benzodioxol-5-ylmethylidene)-1H-imidazol-5-one
Molecular Weight (Da)
307.30
Molecular Formula
C17H13N3O3
SMILES
C1OC2=C(O1)C=C(C=C2)C=C3C(=O)NC(=N3)NC4=CC=CC=C4
Storage & Handling
Storage Instructions
Shipped at 4 °C. Store at -20 °C. Store in the dark. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
