Product Size
50 mg
10 mg
Custom Size
Product Overview
Description
Potent Raf kinase inhibitor.
Biological Description
Potent Raf kinase inhibitor (IC50 = 10 nM). Inhibits Raf-1 activation. Competes for ATP at the protein kinase catalytic site. Supresses DNA synthesis and induces apoptosis. Additionally inhibits p38.
Solubility Overview
Soluble in DMSO to 100 mM and in ethanol to 10 mM.
Chemical Properties
Chemical Name
2-Chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-imidazol-5-yl]phenol
Molecular Weight (Da)
347.80
Molecular Formula
C20H14ClN3O
SMILES
Clc1ccc(cc1O)c2nc(nc2c3ccncc3)c4ccccc4
Storage & Handling
Storage Instructions
Store at 4 °C. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
