Product Size
5 mg
1 mg
Custom Size
Product Overview
Description
CaM kinase II inhibitor. P2X7 antagonist.
Target
CaM kinase II. P2X7.
Biological Description
Cell-permeable, reversible and selective inhibitor of CaM kinase II (IC50 = 500 nM). Interacts with the calmodulin binding site of the enzyme. At higher concentrations reported to inhibit GSK3β, PRAK and MAPKAP-K2. Also potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM).
Solubility Overview
Soluble in DMSO to 100 mM.
Chemical Properties
Chemical Name
4-[(2S)-2-[(5-Isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl] phenylisoquinolinesulfonic acid ester
Molecular Weight (Da)
721.84
Molecular Formula
C38H35N5O6S2
SMILES
O=C([C@H](Cc3ccc(OS(=O)(=O)c2cccc1cnccc12)cc3)N(C)S(=O)(=O)c5cccc4cnccc45)N6CCN(CC6)c7ccccc7
Storage & Handling
Storage Instructions
Store at -20 °C. Store under desiccating conditions. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
