Product Overview
Reactivity
Human (predicted: Horse, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Bat)
Target Information
Alternative Names
bA500C11.2; FLJ27232; Homolog of mouse KIF13A mannose 6 phosphate receptor transporter; KI13A_HUMAN; KIF 13A; Kif13a; Kinesin family member 13A; Kinesin like protein KIF13A; Kinesin like protein RBKIN; Kinesin-like protein KIF13A; Kinesin-like protein RBKIN; RBKIN
Function
Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis.
Tissue Specificity
Widely expressed, with highest levels in heart, brain and skeletal muscle.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage
Upon delivery aliquot and store at -20 °C. Avoid freeze / thaw cycles.
Storage Buffer
0.1% BSA, Tris buffered saline. pH: 6.8.
Preservative
0.09% Sodium Azide
