Product Size
100 tests
Custom Size
Product Information
Sample Type
Inhibitor Compounds
Assay Type
Enzyme activity
Detection Method
Fluorescent
Target Information
Function
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.
Sequence Similarities
Belongs to the GCN5 family. Contains 1 bromo domain. Contains 1 N-acetyltransferase domain.
Alternative Names
CAF; CREBBP associated factor; GCN5; GCN5L; GCN5L1; Histone acetylase PCAF; Histone acetyltransferase KAT2B; Histone acetyltransferase PCAF; K(lysine) acetyltransferase 2B; KAT2B; KAT2B_HUMAN; Lysine acetyltransferase 2B; P; P/CAF; p300/CBP associated factor; P300/CBP-associated factor; Pcaf
Tissue Specificity
Ubiquitously expressed but most abundant in heart and skeletal muscle.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage Instructions
Store at -20 °C. Please refer to protocols.
