JAK2 ELISA Kit

Cat. No.
CLEK-00530221
Product Size
1 x 96 tests Custom Size

Product Information

Reactivity
Mouse, Rat, Human
Sample Type
Cell Lysate
Assay Type
Sandwich (quantitative)
Sensitivity
129.3 pg/mL
Range
390.6 pg/mL-25000 pg/mL
Assay Time
1h
30m
Detection Method
Colorimetric
Form
96-Well Strip Plate

Target Information

Gene ID
Function
Non-receptor tyrosine kinase involved in various processes such as cell cycle progression, apoptosis, mitotic recombination, genetic instability and histone modifications. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors, which constitutes an initiating step in signaling for many members of the cytokine receptor superfamily including the receptors for growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), granulocyte-macrophage colony-stimulating factor (CSF2), thrombopoietin (THPO) and multiple interleukins. Following stimulation with erythropoietin (EPO) during erythropoiesis, it is autophosphorylated and activated, leading to its association with erythropoietin receptor (EPOR) and tyrosine phosphorylation of residues in the EPOR cytoplasmic domain. Also involved in promoting the localization of EPOR to the plasma membrane. Also acts downstream of some G-protein coupled receptors. Plays a role in the control of body weight (By similarity). Mediates angiotensin-2-induced ARHGEF1 phosphorylation. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. Contains 1 FERM domain. Contains 1 protein kinase domain. Contains 1 SH2 domain.
Alternative Names
JAK 2; JAK-2; JAK2; JAK2_HUMAN; Janus Activating Kinase 2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK 10; JTK10; kinase Jak2; OTTHUMP00000043260; THCYT3; Tyrosine protein kinase JAK2; Tyrosine-protein kinase JAK2
Tissue Specificity
Expressed in blood, bone marrow and lymph node.

Shipping & Handling

Shipping
Shipped on dry ice.
Storage Instructions
Store at 4 °C. Please refer to protocols.

For Research Use Only. Not For Clinical Use.

Online Inquiry