Human Von Hippel Lindau/VHL Peptide

Cat. No.: CLPP-00150177

Product Size: 100 µg Custom size

Product Overview

Description
CLPP-00150177 is synthetic human VHL Peptide
Purity
> 70%
Protein Length
Peptide
Animal Free
No
Nature
Synthetic
Species
Human
Form
Liquid
Sequence
MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD

Target Information

Protein Name
VHL
UniProt No.
Alternative Names
Elongin binding protein; G7 protein; HRCA 1; HRCA1; Protein G7; pVHL; RCA 1; RCA1; VHL; VHL 1; VHL_HUMAN; VHL1; VHLH; Von Hippel Lindau; Von Hippel Lindau disease tumor suppressor; von Hippel Lindau syndrome; von Hippel Lindau tumor suppressor; Von Hippel Lindau tumor suppressor, E3 ubiquitin protein ligase; Von Hippel-Lindau disease tumor suppressor
Protein Function
Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.
Tissue Specificity
Expressed in the adult and fetal brain and kidney.
Involvement in Disease
Defects in VHL are cause of susceptibility to pheochromocytoma (PCC); von Hippel-Lindau disease (VHLD); erythrocytosis familial type 2 (ECYT2); renal cell carcinoma (RCC).

Shipping & Handling

Shipping
Shipped at 4 °C.
Storage
Store at -20 °C or -80 °C.

For Research Use Only. Not For Clinical Use.

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