Human TAL1 Knockout Jurkat Cell Lysate

Cat. No.
CLCP-00350653
Product Size
1 Kit

Product Overview

Parental Cell Line
Jurkat
Biosafety Level
BSL-1
Species
Human
Mutation Description
Knockout achieved by CRISPR/Cas9; X = 2 bp insertion; Frameshift: 100%
Knockout Validation
Next Generation Sequencing (NGS)

Cell Line Properties

Tissue
T-cell leukemia
Morphology
Lymphoid
Gender
Male
Form
Liquid
Mycoplasma Free
Yes

Target Information

Gene Name
TAL1
Gene ID
UniProt No.
Gene Function
Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.
Sequence Similarities
Contains 1 basic helix-loop-helix (bHLH) domain.
Post-translational Modifications
Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia.Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells.

Storage & Handling

Cryopreservation Cell Medium
Cell freezing medium - DMSO serum free media, contains 8.7% DMSO in MEM supplemented with methyl cellulose.
Culture Medium
RPMI + 10% FBS
Initial Handling Guidelines
Lyophilizate may be stored at 4 °C. After reconstitution, store at -20 °C for short-term storage or -80 °C for long-term storage.
Storage Instructions
Store at -80 °C. Avoid freeze / thaw cycles.

For Research Use Only. Not For Clinical Use.

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