Product Size
1 x 96 tests
Custom Size
Product Information
Sample Type
Cell Culture Extracts
Assay Type
Sandwich (quantitative)
Range
102 pg/mL-6500 pg/mL
Detection Method
Colorimetric
Target Information
Function
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.
Sequence Similarities
Belongs to the securin family.
Alternative Names
AW555095; C87862; Cut2; EAP 1; EAP1; ESP1 associated protein 1; Esp1-associated protein; hPTTG; MGC126883; MGC138276; Pds1; Pituitary tumor transforming 1; Pituitary tumor transforming protein 1; Pituitary tumor-transforming 1, isoform CRA_a; Pituitary tumor-transforming 1, isoform CRA_b; Pituitary tumor-transforming gene 1; Pituitary tumor-transforming gene 1 protein; PTTG; PTTG 1; PTTG1; PTTG1 protein; PTTG1_HUMAN; Pttg3; Securin; Tumor transforming 1; Tumor transforming protein 1; Tumor-transforming protein 1; TUTR 1; TUTR1
Tissue Specificity
Expressed at low level in most tissues, except in adult testis, where it is highly expressed. Overexpressed in many patients suffering from pituitary adenomas, primary epithelial neoplasias, and esophageal cancer.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage Instructions
Store at 4 °C. Please refer to protocols.
