Human COMP ELISA Kit

Cat. No.
CLEK-00530244
Product Size
1 x 96 tests Custom Size

Product Information

Reactivity
Human
Sample Type
Cell Culture Supernatant, Serum, Cell Lysate, Hep Plasma, Edta Plasma
Assay Type
Sandwich (quantitative)
Sensitivity
< 10 pg/mL
Range
156 pg/mL-10000 pg/mL
Assay Time
3h
30m
Detection Method
Colorimetric
Form
96-Well Strip Plate

Target Information

Gene ID
Function
May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.
Sequence Similarities
Belongs to the thrombospondin family. Contains 4 EGF-like domains. Contains 1 TSP C-terminal (TSPC) domain. Contains 8 TSP type-3 repeats.
Alternative Names
Cartilage oligomeric matrix protein; cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple); Cartilage oligomeric matrix protein precursor; COMP; COMP_HUMAN; EDM 1; EDM1; EPD 1; EPD1; Epiphyseal dysplasia 1; Epiphyseal dysplasia 1 multiple; Epiphyseal dysplasia multiple 1; MED; MGC13181; MGC149768; PSACH; Pseudoachondroplasia; pseudoachondroplasia (epiphyseal dysplasia 1, multiple); THBS 5; THBS5; Thrombospondin 5; Thrombospondin-5; Thrombospondin5; TSP5
Tissue Specificity
Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect.

Shipping & Handling

Shipping
Shipped on dry ice.
Storage Instructions
Store at -20 °C. Please refer to protocols.

For Research Use Only. Not For Clinical Use.

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