Product Overview
Mutation Description
Knockout achieved by using CRISPR/Cas9, homozygous: 11 bp deletion in exon 1.
Knockout Validation
Sanger Sequencing
Tested Applications
Sanger Sequencing
Cell Line Properties
Target Information
Gene Function
Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.
Sequence Similarities
Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. Contains 4 ANK repeats.
Storage & Handling
Cryopreservation Cell Medium
Cell freezing medium - DMSO serum free media, contains 8.7% DMSO in MEM supplemented with methyl cellulose.
Culture Medium
DMEM (High Glucose) + 10% FBS
Initial Handling Guidelines
Lyophilizate may be stored at 4 °C. After reconstitution, store at -20 °C for short-term storage or -80 °C for long-term storage.
Storage Instructions
Store at -80 °C. Avoid freeze / thaw cycles.
