HS-1371, RIP3 Kinase Inhibitor

Inquiry

Cat. No.

CLIA-0130254

Product Size

5 mg 25 mg Custom Size

Product Overview

Description

Potent RIP3 kinase inhibitor.

Purity

> 98%

Form

Solid

Target

RIP3 kinase

Biological Description

Potent RIP3 kinase inhibitor (IC50 = 20.8 nM). It binds to the ATP binding pocket of RIP3 and inhibits ATP binding to prevent RIP3 enzymatic activity in vitro. It inhibits TNF-induced necroptosis but does not inhibit TNF-induced apoptosis, indicating that HS-1371 has a specific inhibitory effect on RIP3-mediated necroptosis via the suppression of RIP3 kinase activity.

Source

Synthetic

CAS Number

2158197-70-5

Solubility Overview

> 10 mg/mL in DMSO.

Chemical Properties

Chemical Name

4-(4-methylphenoxy)-7-(1-piperidin-4-ylpyrazol-4-yl)quinoline

Molecular Weight (Da)

384.47

Molecular Formula

C₂₄H₂₄N₄O

PubChem Identifier

134817449

SMILES

CC1=CC=C(C=C1)OC2=C3C=CC(=CC3=NC=C2)C4=CN(N=C4)C5CCNCC5

Storage & Handling

Storage Instructions

Shipped at 4 °C. Store at -20 °C.

For Research Use Only. Not For Clinical Use.