Product Size
1 mg
5 mg
Custom Size
Product Overview
Description
Potent, highly specific MDM-2/p53 inhibitor.
Alternative Names
Siremadlin
Biological Description
Potent and highly specific MDM-2/p53 inhibitor. It binds to human MDM2 protein with a picomolar Ki value (0.21 nM). It activates p53 and induces robust p53-dependent cell cycle arrest and apoptosis in human p53 wild-type tumor cells.
Solubility Overview
> 50 mg/mL in DMSO.
Chemical Properties
Chemical Name
(4S)-5-(5-chloro-1-methyl-2-oxopyridin-3-yl)-4-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-3-propan-2-yl-4H-pyrrolo[3,4-d]imidazol-6-one
Molecular Weight (Da)
555.41
Molecular Formula
C26H24Cl2N6O4
SMILES
CC(C)N1C2=C(C(=O)N(C2C3=CC=C(C=C3)Cl)C4=CC(=CN(C4=O)C)Cl)N=C1C5=CN=C(N=C5OC)OC
Storage & Handling
Storage Instructions
Shipped at 4 °C. Store at -20 °C.
