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GWL Rabbit Polyclonal Antibody

Cat. No.: CLAB-00231037

Product Size: 20 µL 100 µL Custom Size

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Product Overview

Isotype
IgG
Reactivity
Human
Clonality
Polyclonal
Host Species
Rabbit
Conjugation
Unconjugated
Applications
IHC-P, IP, WB

Target Information

Target Name
MASTL
UniProt No.
Q96GX5
Gene ID
84930
Alternative Names
2700091H24Rik; C88295; FLJ14813; GREATWALL; Greatwall protein kinase; GW; GWL; GWL_HUMAN; hGWL; MAST-L; Mastl; MGC117975; Microtubule associated serine/threonine kinase like; Microtubule-associated serine/threonine-protein kinase-like; RP11 85G18.2; Serine/threonine-protein kinase greatwall; THC2
Function
Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.

Shipping & Handling

Shipping
Shipped on dry ice.
Storage
Upon delivery aliquot and store at -20 °C. Avoid freeze / thaw cycles.
Storage Buffer
Tris citrate/phosphate. pH: 7.
Preservative
0.09% Sodium Azide

For Research Use Only. Not For Clinical Use.

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