Go 6976, PKC Inhibitor

Cat. No.
CLIA-0130110
Product Size
500 μg 100 μg Custom Size

Product Overview

Description
Potent PKC inhibitor. Selective for PKCα and PKCβ.
Purity
> 99%
Form
Solid
Target
PKC
Biological Description
Potent, selective PKC inhibitor (IC50 values are 2.3 and 6.2 nM at PKCα and β1, respectively). Selectively inhibits Ca2+-dependent PKC isoforms over Ca2+-independent. No inhibitory activity at PKCδ, ε or ζ. Antitumor agent. Active in vitro and in vivo.
Source
Synthetic
CAS Number
136194-77-9
Solubility Overview
Soluble in DMSO to 10 mM.

Chemical Properties

Chemical Name
5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile
Molecular Weight (Da)
378.43
Molecular Formula
C24H18N4O
PubChem Identifier
SMILES
CN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O

Storage & Handling

Storage Instructions
Store at -20 °C. Store under desiccating conditions. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

For Research Use Only. Not For Clinical Use.

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