Product Size
50 mg
250 mg
Custom Size
Product Overview
Description
Orally active, Potent, selective EGFR tyrosine kinase inhibitor.
Target
EGFR tyrosine kinase
Biological Description
Orally active, potent, selective EGFR (Epidermal growth factor receptor) tyrosine kinase inhibitor (IC50 = 33 nM). Inhibits EGF-stimulated EGFR autophosphorylation and inhibits tumor growth in vivo. Enhances efficacy of cytotoxic agents. Inhibits growth factor production and angiogenesis. Clinically useful anticancer agent.
Solubility Overview
Soluble in DMSO to 100 mM.
Chemical Properties
Chemical Name
N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
Molecular Weight (Da)
446.90
Molecular Formula
C22H24ClFN4O3
SMILES
COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4
Storage & Handling
Storage Instructions
Shipped at room temperature. Store at -20 °C. Store under desiccating conditions.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
