Product Size
5 mg
25 mg
Custom Size
Product Overview
Description
A selective PRMT1 inhibitor.
Alternative Names
4,4'-(2,5-Furandiyl)bis-benzenecarboximidamide dihydrochloride; DB75
Biological Description
A potent, selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 9.4 μM). Displays selectivity over PRMT5, PRMT6 and CARM1 (IC50 values are 166, 283 and >400 μM respectively). Inhibits cell proliferation in leukemia cell lines.
Solubility Overview
> 15 mg/mL in Water> 15 mg/mL in DMSO.
Chemical Properties
Chemical Name
4-[5-(4-carbamimidoylphenyl)furan-2-yl]benzenecarboximidamide
Molecular Weight (Da)
377.27
Molecular Formula
C18H16N4O
SMILES
C1=CC(=CC=C1C2=CC=C(O2)C3=CC=C(C=C3)C(=N)N)C(=N)N.Cl.Cl
Storage & Handling
Storage Instructions
Shipped at 4 °C. Store at -20 °C. Store under desiccating conditions.
