Product Size
50 mg
250 mg
Custom Size
Product Overview
Description
Selective type II 5α-reductase inhibitor.
Target
Type II 5 alpha-reductase
Biological Description
Type II 5α-reductase inhibitor (IC50 values are 11.3 and 313 nM at type II and type I respectively). Reduces prostate gland size. Suppresses conversion of testosterone to dihydrotestosterone. Active in vivo and orally active.
Solubility Overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM.
Chemical Properties
Chemical Name
(4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(1,1-Dimethylethyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro- 4a,6a-dimethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxamide
Molecular Weight (Da)
372.55
Molecular Formula
C23H36N2O2
SMILES
CC(C)(C)NC(=O)[C@H]4CC[C@@H]3[C@]4(C)CC[C@H]1[C@H]3CC[C@H]2NC(=O)C=C[C@]12C
Storage & Handling
Storage Instructions
Store at room temperature. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
