Product Size
10 mg
100 mg
Custom Size
Product Overview
Description
Potent EGFR tyrosine kinase inhibitor.
Alternative Names
CP-358774; Erlotinib HCl; NSC718781; OSI-744; OSI774; Tarceva
Target
EGFR tyrosine kinase
Biological Description
Potent EGFR tyrosine kinase inhibitor (IC50 = 2 nM). Decreases EGFR autophosphorylation in tumor cells. Potent inhibitor of mutant JAK2-V617F. Weaker inhibitor of ErbB-2 kinase (Ki = 1 μM) and ErbB-4 kinase (Ki = 1.5 μM). Clinically effective agent for non-small cell lung cancer (NSCLC).
Solubility Overview
Soluble in DMSO to 25 mM (with warming).
Chemical Properties
Chemical Name
N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride
Molecular Weight (Da)
429.90
Molecular Formula
C22H23N3O4.HCl
SMILES
COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC.Cl
Storage & Handling
Storage Instructions
Shipped at room temperature. Store at -20 °C. Store under desiccating conditions.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
