Product Size
1 x 96 tests
Custom Size
Product Information
Reactivity
Mouse, Human (predicted: Rat)
Sample Type
Cell Lysate, Tissue Homogenate
Assay Type
Semi-quantitative
Detection Method
Colorimetric
Target Information
Function
Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
Sequence Similarities
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Contains 1 protein kinase domain.
Alternative Names
ERK 1; ERK 2; ERK-1; ERK-2; ERK1; erk1/2; ERK2; ERT1; ERT2; Extracellular signal regulated kinase 1; Extracellular signal-regulated kinase 1; Extracellular signal-regulated kinase 2; HS44KDAP; HUMKER1A; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAP kinase 2; MAP kinase 3; MAP kinase isoform p42; MAP kinase isoform p44; MAPK 1; MAPK 2; MAPK 3; Mapk1; MAPK2; MAPK3; Microtubule-associated protein 2 kinase; Mitogen-activated protein kinase 1; Mitogen-activated protein kinase 2; Mitogen-activated protein kinase 3; MK01_HUMAN; p38; p40; p41; p41mapk; p42-MAPK; P42MAPK; p44-ERK1; p44-MAPK; p44ERK1; p44MAPK; PRKM 2; PRKM1; PRKM2; PRKM3; protein tyrosine kinase ERK2
Shipping & Handling
Shipping
Shipped on dry ice.
Storage Instructions
Store at 4 °C. Please refer to protocols.
