Alternative Names
ERK 1; ERK 2; ERK-1; ERK-2; ERK1; erk1/2; ERK2; ERT1; ERT2; Extracellular signal regulated kinase 1; Extracellular signal-regulated kinase 1; Extracellular signal-regulated kinase 2; HS44KDAP; HUMKER1A; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAP kinase 2; MAP kinase 3; MAP kinase isoform p42; MAP kinase isoform p44; MAPK 1; MAPK 2; MAPK 3; Mapk1; MAPK2; MAPK3; Microtubule-associated protein 2 kinase; Mitogen-activated protein kinase 1; Mitogen-activated protein kinase 2; Mitogen-activated protein kinase 3; MK01_HUMAN; p38; p40; p41; p41mapk; p42-MAPK; P42MAPK; p44-ERK1; p44-MAPK; p44ERK1; p44MAPK; PRKM 2; PRKM1; PRKM2; PRKM3; protein tyrosine kinase ERK2
Function
Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2. Phosphorylates SPZ1. Phosphorylates heat shock factor protein 4 and ARHGEF2.Acts as a transcriptional repressor. Binds to a AAA consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
Storage Buffer
50% Glycerol (glycerin, glycerine), PBS, 0.87% Sodium chloridePBS without Mg2+ and Ca2+. pH: 7.40.
