Emerin Rabbit Polyclonal Antibody

Cat. No.: CLAB-00230991

Product Size: 20 µL 100 µL Custom Size

Product Overview

Isotype
IgG
Reactivity
Human (predicted: Mouse, Rat, Cow)
Clonality
Polyclonal
Host Species
Rabbit
Conjugation
Unconjugated
Applications
ICC/IF, IP, WB

Target Information

Target Name
EMD
UniProt No.
Gene ID
Alternative Names
EDMD; Emd; EMD_HUMAN; Emerin; Emery Dreifuss muscular dystrophy; STA
Function
Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.
Tissue Specificity
Skeletal muscle, heart, colon, testis, ovary and pancreas.

Shipping & Handling

Shipping
Shipped on dry ice.
Storage
Store at 4 °C short term (1-2 weeks). Upon delivery aliquot. Store at -20 °C or -80 °C. Avoid freeze / thaw cycle.
Storage Buffer
PBSBatches of this product that have a concentration < 1 mg/mL may have BSA added as a stabilising agent. If you would like information about the formulation of a specific lot, please contact our scientific support team who will be happy to help. pH: 7.40.
Preservative
0.02% Sodium Azide

For Research Use Only. Not For Clinical Use.

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