Product Size
50 mg
10 mg
Custom Size
Product Overview
Description
Non-nucleoside reverse transcriptase inhibitor.
Alternative Names
EFV; Sustiva
Target
Reverse transcriptase
Biological Description
Non-nucleoside reverse transcriptase inhibitor (NNRTI). Exhibits antiviral and anticancer activities. Clinically used to treat HIV type 1 infection. Prevents RNA plus-strand initiation (IC50 = 17 nM). Induces autophagy and mitochondrial changes in neurons. Inhibits cellular proliferation and increases activation of p53 in various cancer cell lines.
Solubility Overview
Soluble in DMSO to 5 mM.
Chemical Properties
Chemical Name
(4S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
Molecular Weight (Da)
315.67
Molecular Formula
C14H9ClF3NO2
SMILES
C1CC1C#C[C@]2(C3=C(C=CC(=C3)Cl)NC(=O)O2)C(F)(F)F
Storage & Handling
Storage Instructions
Store at -20 °C (desiccating conditions).
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
