Product Size
50 mg
10 mg
Custom Size
Product Overview
Description
Casein kinase II inhibitor.
Alternative Names
Benzimidazole; DiCl-RB; NSC 401575
Target
Casein kinase 2 (CK2)
Biological Description
Casein kinase II inhibitor (Ki values are 23 and 48 μM for CKII and CKI, respectively). Inhibitor of RNA polymerase II transcription in vitro and in vivo. Shown to inhibit cyclin C/CDK8 (IC50 = 17 μM) and cyclin H/CDK7/p38 (IC50 = 18 μM) signaling.
Solubility Overview
Soluble in DMSO to 25 mM.
Chemical Properties
Chemical Name
5,6-Dichloro-1-β-D-ribofuranosyl-1H-benzimidazole
Molecular Weight (Da)
319.14
Molecular Formula
C12H12Cl2N2O4
SMILES
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2cc(Cl)c(Cl)cc12
Storage & Handling
Storage Instructions
Store at -20 °C. Store under desiccating conditions. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
