Docetaxel, Cytotoxic Agent

Inquiry

Cat. No.

CLIA-0130106

Product Size

50 mg 10 mg Custom Size

Product Overview

Description

Potent cytotoxic agent.

Purity

> 99%

Form

Solid

Biological Description

Potent cytotoxic agent in vitro (IC50 = 2 nM). Disrupts microtubule assembly and arrests cell divison at G2/M phase. Induces apoptosis. Antitumor agent. Active in vivo and in vitro.

Source

Synthetic

CAS Number

114977-28-5

Solubility Overview

Soluble in DMSO to 100 mM and in ethanol to 100 mM.

Chemical Properties

Chemical Name

(αR,βS)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxybenzenepropanoic acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester

Molecular Weight (Da)

807.89

Molecular Formula

C₄₃H₅₃NO₁₄

PubChem Identifier

148124

SMILES

CC(C)(C)OC(=O)N[C@@H](c1ccccc1)[C@@H](O)C(=O)O[C@H]5C[C@@]6(O)[C@@H](OC(=O)c2ccccc2)[C@H]3[C@@](C)([C@@H](O)C[C@H]4OC[C@@]34OC(C)=O)C(=O)[C@H](O)C(=C5C)C6(C)C

Storage & Handling

Storage Instructions

Store at 4 °C. Store under desiccating conditions. The product can be stored for up to 12 months.

Handling

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

For Research Use Only. Not For Clinical Use.