Product Size
5 mg
25 mg
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Product Overview
Description
A selective BMP inhibitor.
Biological Description
An analog of Dorsomorphin that acts as a highly selective Bone morphogenetic protein (BMP) inhibitor. DMH-1 exclusively targets the BMP but not the VEGF pathway. Blocks BMP4-induced phosphorylation of Smads 1, 5 and 8 in HEK293 cells. Promotes neurogenesis in human induced pluripotent stem cells (iPSCs) when used in combination with SB-431542.
Solubility Overview
Soluble in DMSO to 10 mM.
Chemical Properties
Chemical Name
4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline
Molecular Weight (Da)
380.44
Molecular Formula
C24H20N4O
SMILES
CC(C)OC1=CC=C(C=C1)C2=CN3C(=C(C=N3)C4=CC=NC5=CC=CC=C45)N=C2
Storage & Handling
Storage Instructions
Shipped at 4 °C. Store at -20 °C. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
