Dinaciclib, Cyclin-dependent Kinase (CDK) Inhibitor

Cat. No.
CLIA-0130230
Product Size
5 mg 25 mg Custom Size

Product Overview

Description
Novel, Potent, selective cyclin-dependent kinase (CDK) inhibitor.
Purity
> 98%
Form
Solid
Alternative Names
MK-7965; SCH 727965; SCH727965
Target
Cyclin-dependent kinase (CDK)
Biological Description
Novel, potent, selective cyclin-dependent kinase (CDK) inhibitor displaying selectivity for CDK1, CDK2, CDK5 and CDK9 (IC50 values are 3, 1, 1 and 4 nM respectively). Potent DNA replication inhibitor that blocks thymidine incorporation in A2780 ovarian cancer cells (IC50 = 4 nM).
Source
Synthetic
CAS Number
779353-01-4
Solubility Overview
Soluble in DMSO to 50 mM.

Chemical Properties

Chemical Name
2-[(2S)-1-[3-ethyl-7-[(1-oxidopyridin-1-ium-3-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]piperidin-2-yl]ethanol
Molecular Weight (Da)
396.49
Molecular Formula
C21H28N6O2
PubChem Identifier
SMILES
CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCC[C@H]4CCO

Storage & Handling

Storage Instructions
Shipped at room temperature. Store at -20 °C. Store under desiccating conditions.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

For Research Use Only. Not For Clinical Use.

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