Defactinib, FAK Inhibitor

Inquiry

Cat. No.

CLIA-0130233

Product Size

5 mg 25 mg Custom Size

Product Overview

Description

Potent FAK inhibitor.

Purity

> 98%

Form

Solid

Alternative Names

PF-04554878; VS-6063

Target

FAK

Biological Description

Potent FAK inhibitor. Prevents tumor invasion and dissemination. Preferentially targets cancer stem cells in mouse xenograft models. Orally bioavailable.

Source

Synthetic

CAS Number

1073154-85-4

Solubility Overview

Soluble in DMSO to 25 mM.

Chemical Properties

Chemical Name

N-Methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide

Molecular Weight (Da)

510.49

Molecular Formula

C₂₀H₂₁F₃N₈O₃S

PubChem Identifier

25117126

SMILES

CNC(=O)C1=CC=C(C=C1)NC2=NC=C(C(=N2)NCC3=NC=CN=C3N(C)S(=O)(=O)C)C(F)(F)F

Storage & Handling

Storage Instructions

Shipped at room temperature. Store at -20 °C. Store under desiccating conditions.

For Research Use Only. Not For Clinical Use.