Product Size
5 mg
25 mg
Custom Size
Product Overview
Description
Potent mutant B-Raf V600E inhibitor.
Alternative Names
GSK2118436; Tafinlar
Target
Mutant B-Raf V600E
Biological Description
Potent, ATP-competitive mutant B-Raf V600E inhibitor (IC50 = 0.7 nM), with selectivity versus wild-type B-Raf (IC50 = 5.2 nM) and c-RAf (IC50 = 6.3 nM) in cell-free assays. Antitumor activity in vivo in mouse models of B-Raf V600E melanoma.
Solubility Overview
Soluble in DMSO to 50 mM (with warming).
Chemical Properties
Chemical Name
N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
Molecular Weight (Da)
519.56
Molecular Formula
C23H20F3N5O2S
SMILES
CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F
Storage & Handling
Storage Instructions
Shipped at room temperature. Store at -20 °C.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
