Product Size
50 mg
10 mg
Custom Size
Product Overview
Description
Selective, reversible DNA-dependent protein kinase and mTOR inhibitor.
Target
DNA-dependent protein kinase and mTOR
Biological Description
Selective, reversible DNA-dependent protein kinase and mTOR inhibitor (IC50 values are 0.28 and 5.3 μM respectively). No affinity for PI3K, ATM and ATR (IC50 values are >100 μM). Able to induce apoptosis in vitro. Cell-permeable.
Solubility Overview
Soluble in DMSO to 10 mM.
Chemical Properties
Chemical Name
2-(4-Morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one
Molecular Weight (Da)
281.31
Molecular Formula
C16H15N3O2
SMILES
O=C2C=C(N=C1c3ccccc3C=CN12)N4CCOCC4
Storage & Handling
Storage Instructions
Store at room temperature. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
