Product Size
1 mg
5 mg
Custom Size
Product Overview
Description
An inhibitor of p38 alpha-mediated MK2a phosphorylation.
Biological Description
A substrate-selective inhibitor of p38α MAPK that selectively inhibits p38α-dependent phosphorylation of mitogen-activated protein kinase-activated protein kinase 2 (MK2a) with a K(i)(app) of 330 nM. It does not inhibit the phosphorylation of ATF-2 and MBP. It inhibits proliferation of U87, A172, and U251 glioblastoma cells with EC50 values of 0.6-1 μM by inhibition of tubulin polymerization and induction of apoptosis.
Solubility Overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM.
Chemical Properties
Chemical Name
4-[4-(2-fluorophenyl)phenyl]-N-(4-hydroxyphenyl)butanamide
Molecular Weight (Da)
349.40
Molecular Formula
C22H20FNO2
SMILES
C1=CC=C(C(=C1)C2=CC=C(C=C2)CCCC(=O)NC3=CC=C(C=C3)O)F
Storage & Handling
Storage Instructions
Shipped at room temperature. Store at -20 °C. Store in the dark.
