Product Size
100 mg
25 mg
Custom Size
Product Overview
Description
Antimetabolite agent. Purine analogue.
Biological Description
Antimetabolite agent. Purine analogue. Deoxycytidine kinase substrate. Competes with dATP for DNA polymerase-α and -ε. Potent ribonucleotide reductase inhibitor (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Shows antitumor effects in vivo.
Solubility Overview
Soluble in water to 10 mM and in DMSO to 100 mM.
Chemical Properties
Chemical Name
(2R,3R,4S,5R)-5-(6-Amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
Molecular Weight (Da)
303.68
Molecular Formula
C10H11ClFN5O3
SMILES
C1=NC2=C(N1C3C(C(C(O3)CO)O)F)N=C(N=C2N)Cl
Storage & Handling
Storage Instructions
Store at room temperature. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
