Product Size
1 g
100 mg
Custom Size
Product Overview
Description
Metal chelator and ionophore.
Biological Description
Metal chelator and ionophore with beneficial effects in animal models of neurodegenerative diseases (Alzheimer's, Parkinson's and Huntington's disease). Effects on Alzheimer's disease attributed to copper and zinc chelation or increased level of a metalloprotease. Other actions reported including iron chelation, inhibition of Huntington expression from its mRNA, proteasome inhibition when complexed with copper, and stimulation of tumor necrosis factor-α secretion. Also inhibitor of CLK-1/MCLK1 (an aging-associated protein).
Solubility Overview
Soluble in DMSO to 100 mM.
Chemical Properties
Chemical Name
5-Chloro-8-hydroxy-7-iodoquinoline
Molecular Weight (Da)
305.50
Molecular Formula
C9H5ClINO
SMILES
Oc1c(I)cc(Cl)c2cccnc12
Storage & Handling
Storage Instructions
Store at room temperature. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
