Product Overview
Applications
ICC/IF, IHC-P, WB
Target Information
Alternative Names
1700030C23Rik; 5730583A19Rik; B130045P17Rik; CLAP1_HUMAN; clasp1; CLIP associating protein 1; CLIP associating protein CLASP1; CLIP-associating protein 1; Cytoplasmic linker associated protein 1; Cytoplasmic linker-associated protein 1; DKFZp686D1968; DKFZp686H2039; FLJ33821; FLJ41222; hOrbit1; KIAA0622; MAST1; MGC131895; mKIAA0622; Multiple asters 1; Multiple asters homolog 1; Protein Orbit homolog 1
Function
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network. Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage
Upon delivery aliquot. Store at -20 °C or -80 °C. Avoid freeze / thaw cycle.
Storage Buffer
1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine). pH: 7.00.
Preservative
0.01% Thimerosal (merthiolate)
