Product Size
5 mg
25 mg
Custom Size
Product Overview
Description
Potent, selective type II JAK2 inhibitor.
Biological Description
CHZ868 is a potent and selective type II JAK2 inhibitor (IC50 = 110 nM). JAK2 and MPL mutant cell lines are sensitive to CHZ868, including type I JAK inhibitor persistent cells. CHZ868 displays significant activity in murine MPN models and induces reductions in mutant allele burden not observed with type I JAK inhibitors.
Solubility Overview
> 100 mg/mL in DMSO.
Chemical Properties
Chemical Name
N-[4-[2-(2,4-difluoroanilino)-1,4-dimethylbenzimidazol-5-yl]oxypyridin-2-yl]acetamide
Molecular Weight (Da)
423.42
Molecular Formula
C22H19F2N5O2
SMILES
CC1=C(C=CC2=C1N=C(N2C)NC3=C(C=C(C=C3)F)F)OC4=CC(=NC=C4)NC(=O)C
Storage & Handling
Storage Instructions
Shipped at 4 °C. Store at -20 °C. Store in the dark. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
