CHIR99021, GSK3 Inhibitor

Cat. No.
CLIA-0130135
Product Size
1 mg 5 mg Custom Size

Product Overview

Description
Potent, highly selective GSK3 inhibitor.
Purity
> 98%
Form
Solid
Target
GSK3
Biological Description
Potent, highly selective aminopyrimidine GSK3 inhibitor (IC50 values are 6.7 and 10 nM at GSK3β and GSK3α, respectively). Exhibits >500-fold selectivity for GSK3 against 20 closely related protein kinases and >800-fold selectivity for 23 additional enzymes and 22 receptors. Promotes self-renewal of mouse and human ESC due to β-catenin and c-Myc protein level stabilization. Commonly used in multiple stages of organoid generation.
Source
Synthetic
CAS Number
252917-06-9
Solubility Overview
Soluble in DMSO to 100 mM.

Chemical Properties

Chemical Name
6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
Molecular Weight (Da)
465.34
Molecular Formula
C22H18Cl2N8
PubChem Identifier
SMILES
N#CC(C=N1)=CC=C1NCCNC2=NC=C(C3=NC(C)=CN3)C(C4=CC=C(Cl)C=C4Cl)=N2

Storage & Handling

Storage Instructions
Shipped at 4 °C. Store at -20 °C. Store under desiccating conditions. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

For Research Use Only. Not For Clinical Use.

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