Product Size
50 mg
10 mg
Custom Size
Product Overview
Description
MNK inhibitor.
Biological Description
Low-molecular-weight kinase inhibitor of MAP-kinase interacting kinase-1 (MNK1) and MNK2 (IC50 values are 0.87 and 1.6 μM, respectively). Inhibits a range of other kinases (IC50 values in μM shown in brackets) including: CKI (0.51) Aurora B (2.5) DYRK3 (3.2) SGK1( 2.7) BRSK2 (1.1) and Lck (2.5).
Solubility Overview
Soluble in DMSO to 100 mM.
Chemical Properties
Chemical Name
N3-(4-Fluorophenyl)-1H-pyrazolo-[3,4-d]pyrimidine-3,4-diamine
Molecular Weight (Da)
244.23
Molecular Formula
C11H9FN6
SMILES
Fc1ccc(cc1)Nc3nnc2ncnc(N)c23
Storage & Handling
Storage Instructions
Store at 4 °C. The product can be stored for up to 12 months.
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20 °C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
