Product Overview
Reactivity
Pig, Orangutan, Gibbon, Human, Monkey, Chimpanzee
Target Information
Alternative Names
CEP63; Centrosomal protein of 63 kDa; Centrosome protein CEP63; Centrosomal protein 63kDa
Function
Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks , is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression.
Shipping & Handling
Shipping
Shipped on dry ice.
Storage
Short term: store at 4 °C. Long term: add glycerol to 40-50%, aliquot to avoid freeze-thaw cycles, and store at -20 °C. Protect from light.
