CEP63 Rabbit Polyclonal Antibody (aa114-163)

Cat. No.: CLAB-00230592

Product Size: 20 µL 100 µL Custom Size

Product Overview

Reactivity
Pig, Orangutan, Gibbon, Human, Monkey, Chimpanzee
Clonality
Polyclonal
Host Species
Rabbit
Conjugation
Biotin
Applications
WB

Target Information

Target Name
CEP63
UniProt No.
Gene ID
Alternative Names
CEP63; Centrosomal protein of 63 kDa; Centrosome protein CEP63; Centrosomal protein 63kDa
Function
Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks , is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression.

Shipping & Handling

Shipping
Shipped on dry ice.
Storage
Short term: store at 4 °C. Long term: add glycerol to 40-50%, aliquot to avoid freeze-thaw cycles, and store at -20 °C. Protect from light.

For Research Use Only. Not For Clinical Use.

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